RAB33B

Across TCGA patient cohorts, RAB33B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB33B-associated genes across cancer lineages are ER-alpha, Ku80, and MEK1. Each is linked with RAB33B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB33B-to-partner and partner-to-RAB33B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by RAB33B-low versus RAB33B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB33B→partner) and Y-score (partner→RAB33B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-1.245	-3.169	.003	.019	3	1
UCEC	Ku80 →	+0.350	+2.183	.004	.035	3	1
UCEC	MEK1 →	+0.502	+3.321	.008	.010	3	1
UCEC	Notch1 →	+0.266	+3.179	<.001	.010	3	1
UCEC	Annexin_VII →	-0.159	-3.321	.029	.010	3	1
UCEC	ATM →	-0.820	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ER-alpha by RAB33B expression — UCEC

Explore this box plot interactively →