RAB33B

Across TCGA pan-cancer cohorts, RAB33B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RAB33B data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RAB33B RNA is associated with better overall survival. In most high-consensus cancer types, elevated RAB33B expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, SKCM, and LGG are the cancer types where RAB33B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.713	0.541	<.001	136	view →
SKCM	OS	Median	III,IV	0.482	0.254	.001	57	view →
LGG	OS	Median	All	0.327	0.575	<.001	54	view →
UVM	DFS	Quartile	III,IV	0.170	0.824	.002	46	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
LUAD	DFS	Quartile	IV	0.911	0.388	.002	21	view →
THCA	OS	Quartile	II,III,IV	0.818	1.000	.011	17	view →
DLBC	DFS	Median	All	0.622	0.915	.010	17	view →
SCLC	DFS	Median	All	0.375	0.593	.012	16	view →
KICH	OS	Median	II,III,IV	0.798	0.969	.007	12	view →
UCS	DFS	Tertile	IV	0.942	0.364	.024	12	view →
COAD	DFS	Quartile	All	0.712	0.506	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RAB33B–KIRC (OS)

Open the KIRC breakdown →