RAB2A

Across TCGA pan-cancer cohorts, RAB2A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RAB2A data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RAB2A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB2A expression acts as an unfavorable survival marker, although some lineages such as LGG and SCLC show a favorable association.

UVM, UCEC, and HNSC are the cancer types where RAB2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.421	0.748	<.001	140	view →
UCEC	DFS	Median	All	0.558	0.717	<.001	74	view →
HNSC	OS	Quartile	III,IV	0.538	0.907	<.001	47	view →
LGG	DFS	Median	All	0.496	0.306	<.001	47	view →
BRCA	OS	Tertile	All	0.522	0.670	<.001	46	view →
CESC	DFS	Tertile	All	0.391	0.637	.008	30	view →
SARC	OS	Quartile	All	0.351	0.614	<.001	30	view →
KIRP	DFS	Median	All	0.489	0.693	.001	28	view →
KICH	OS	Median	II,III,IV	0.646	0.959	.005	25	view →
ESCA	DFS	Median	III,IV	0.325	0.536	.016	16	view →
SCLC	DFS	Tertile	All	0.549	0.250	.002	16	view →
MESO	DFS	Quartile	IV	0.800	0.285	.015	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RAB2A–UVM (DFS)

Open the UVM breakdown →