RAB27B

Across TCGA pan-cancer cohorts, RAB27B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RAB27B data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RAB27B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RAB27B expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where RAB27B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.984	0.364	.013	8	view →
CCRCC	DFS	Quartile	III,IV	0.322	0.880	.004	6	view →
UCEC	OS	Median	All	0.966	0.852	.026	4	view →
LUAD	OS	Median	II,III,IV	0.429	0.911	.008	2	view →
HNSC	OS	Median	III,IV	1.000	0.948	.043	1	view →
LSCC	DFS	Tertile	All	0.655	0.849	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RAB27B–PDAC (DFS)

Open the PDAC breakdown →