RAB27B

Across TCGA pan-cancer cohorts, RAB27B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RAB27B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAB27B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAB27B is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where RAB27B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB27B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.857	<.001	11	view →
CCRCC	All	III,IV	+0.405	<.001	11	view →
LSCC	Female	All	−0.883	<.001	9	view →
COAD	Male	III,IV	−0.481	<.001	9	view →
LUAD	Female	All	+0.523	<.001	2	view →
PDAC	Male	IV	+0.440	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RAB27B–HNSC

Open the HNSC breakdown →