RAB27A

Across TCGA pan-cancer cohorts, RAB27A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RAB27A data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RAB27A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB27A expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where RAB27A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.158	0.893	.001	23	view →
CCRCC	OS	Quartile	III,IV	0.545	0.987	.015	9	view →
PDAC	DFS	Tertile	III,IV	0.562	0.169	.020	5	view →
GBM	DFS	Tertile	All	0.633	0.824	.016	4	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	2	view →
LSCC	DFS	Median	All	0.828	0.498	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RAB27A–LUAD (DFS)

Open the LUAD breakdown →