RAB27A

Across TCGA pan-cancer cohorts, RAB27A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RAB27A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RAB27A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB27A is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

THCA, COAD, and LUSC are the cancer types where RAB27A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB27A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.647	<.001	11	view →
COAD	Female	All	−1.500	<.001	11	view →
LUSC	Male	II,III,IV	−1.745	<.001	8	view →
BLCA	All	III,IV	−0.844	<.001	7	view →
KICH	All	All	−0.894	<.001	5	view →
READ	All	All	−1.412	.001	2	view →
UCEC	All	All	−0.773	.002	2	view →
LIHC	All	II,III,IV	−0.414	.043	2	view →
LUAD	All	All	−0.287	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RAB27A–THCA

Open the THCA breakdown →