RAB27A

Across TCGA patient cohorts, RAB27A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB27A-associated genes across cancer lineages are JNK2, Ku80, and STAT3_pY705. Each is linked with RAB27A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB27A-to-partner and partner-to-RAB27A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by RAB27A-low versus RAB27A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB27A→partner) and Y-score (partner→RAB27A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.231	+2.817	.026	.036	3	1
UCEC	Ku80 →	+0.277	+2.820	.025	.035	3	1
UCEC	STAT3_pY705 →	-0.516	-2.990	<.001	.036	2	1
UCEC	Tuberin →	+0.505	+3.321	<.001	.010	2	1
UCEC	MEK1 →	+0.467	+3.321	.014	.010	1	1
UCEC	C-Raf →	+0.313	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK2 by RAB27A expression — UCEC

Explore this box plot interactively →