RAB1B

Across TCGA patient cohorts, RAB1B mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB1B-associated genes across cancer lineages are ATM, eIF4E, and A-Raf_pS299. Each is linked with RAB1B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB1B-to-partner and partner-to-RAB1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RAB1B-low versus RAB1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB1B→partner) and Y-score (partner→RAB1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.479	-2.584	.023	.011	3	2
UCEC	eIF4E →	+0.213	+2.584	.030	.011	3	1
UCEC	A-Raf_pS299 →	-0.241	-3.459	<.001	.005	3	1
UCEC	Ku80 →	+0.365	+2.598	<.001	.006	3	1
UCEC	MEK1 →	+0.456	+2.321	.007	.034	3	1
UCEC	P-Cadherin →	-0.155	-3.311	.021	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by RAB1B expression — UCEC

Explore this box plot interactively →