RAB14

Across TCGA patient cohorts, RAB14 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB14-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and ERK2. Each is linked with RAB14 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB14-to-partner and partner-to-RAB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by RAB14-low versus RAB14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB14→partner) and Y-score (partner→RAB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.627	+2.115	.010	.019	3	2
UCEC	EGFR_pY1068 →	-0.222	-2.115	.042	.019	3	1
UCEC	ERK2 →	+0.196	+2.115	.020	.019	3	1
UCEC	JNK2 →	+0.210	+2.179	.015	.034	3	1
UCEC	Ku80 →	+0.289	+2.128	.005	.010	3	1
UCEC	MEK1 →	+0.484	+3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Cyclin-B1 by RAB14 expression — UCEC

Explore this box plot interactively →