RAB10

Across TCGA patient cohorts, RAB10 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB10-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and INPP4B. Each is linked with RAB10 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB10-to-partner and partner-to-RAB10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RAB10-low versus RAB10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB10→partner) and Y-score (partner→RAB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.248	-1.874	.011	.049	3	1
UCEC	FoxM1 →	+0.237	+2.000	.019	.010	3	1
UCEC	INPP4B →	-0.293	-2.459	.021	.018	3	1
UCEC	Ku80 →	+0.344	+2.515	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.339	+3.459	.007	.005	3	1
UCEC	p70-S6K_pT389 →	-0.195	-1.797	.009	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1068 by RAB10 expression — UCEC

Explore this box plot interactively →