RAB10

Across TCGA pan-cancer cohorts, RAB10 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RAB10 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RAB10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RAB10 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

LIHC, KIRC, and PAAD are the cancer types where RAB10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.607	0.763	<.001	75	view →
KIRC	OS	Quartile	All	0.743	0.521	<.001	73	view →
PAAD	OS	Tertile	All	0.266	0.549	<.001	60	view →
UVM	DFS	Quartile	III,IV	0.170	0.914	<.001	46	view →
LUAD	OS	Quartile	All	0.605	0.802	<.001	30	view →
MESO	DFS	Median	II,III,IV	0.290	0.611	.006	29	view →
ACC	DFS	Quartile	All	0.308	0.797	<.001	26	view →
UCEC	DFS	Tertile	All	0.606	0.824	.002	24	view →
BLCA	OS	Tertile	II,III,IV	0.626	0.738	.014	22	view →
KICH	DFS	Median	II,III,IV	0.571	0.920	.005	20	view →
LUSC	DFS	Quartile	II,III,IV	0.708	0.502	.006	20	view →
LGG	OS	Median	All	0.752	0.917	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RAB10–LIHC (OS)

Open the LIHC breakdown →