R3HDML

Across TCGA pan-cancer cohorts, R3HDML Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated R3HDML data layer compared with 18 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher R3HDML Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated R3HDML expression acts as an unfavorable survival marker.

COAD, LUAD, and PCPG are the cancer types where R3HDML Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.035	0.698	<.001	21	view →
LUAD	OS	Median	III,IV	0.004	0.665	<.001	15	view →
PCPG	OS	Median	All	0.009	0.946	<.001	12	view →
LGG	OS	Median	All	0.147	0.811	<.001	12	view →
BLCA	OS	Median	All	0.228	0.720	.010	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

R3HDML–COAD (DFS)

Open the COAD breakdown →