R3HDM2

Across TCGA patient cohorts, R3HDM2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible R3HDM2-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Akt_pT308. Each is linked with R3HDM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HDM2-to-partner and partner-to-R3HDM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by R3HDM2-low versus R3HDM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDM2→partner) and Y-score (partner→R3HDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.287	-2.807	.001	.002	3	2
UCEC	MEK1 →	+0.429	+3.523	<.001	<.001	3	2
UCEC	Akt_pT308 →	+0.495	+1.362	.026	.037	3	2
UCEC	C-Raf →	+0.132	+2.222	.009	.010	3	2
COAD	PKC-a →	-0.318	-3.161	.021	.019	3	1
COAD	Axl →	-0.328	-3.151	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

EGFR_pY1068 by R3HDM2 expression — UCEC

Explore this box plot interactively →