R3HDM2

Across TCGA pan-cancer cohorts, R3HDM2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated R3HDM2 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher R3HDM2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated R3HDM2 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

UCS, KICH, and CESC are the cancer types where R3HDM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	II,III,IV	0.700	0.277	<.001	36	view →
KICH	OS	Tertile	All	0.528	1.000	<.001	36	view →
CESC	DFS	Median	III,IV	0.247	0.723	.004	32	view →
BRCA	DFS	Median	III,IV	0.929	0.823	.001	29	view →
COAD	DFS	Quartile	All	0.698	0.853	.012	28	view →
BLCA	DFS	Median	All	0.232	0.458	.019	24	view →
LGG	OS	Median	All	0.615	0.404	.002	18	view →
ACC	DFS	Quartile	All	0.231	0.603	.006	16	view →
HNSC	OS	Median	III,IV	0.580	0.766	.020	16	view →
PAAD	OS	Tertile	All	0.609	0.307	.011	12	view →
LUSC	DFS	Tertile	III,IV	0.549	1.000	.026	12	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

R3HDM2–UCS (OS)

Open the UCS breakdown →