R3HDM2

Across TCGA cell cohorts, R3HDM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,700 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible R3HDM2-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Cytosolic transport, and Cilium or flagellum-dependent cell motility. Each is linked with R3HDM2 in more than 16 cancer types. Because this analysis shows association rather than direction, both R3HDM2-to-partner and partner-to-R3HDM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by R3HDM2-low versus R3HDM2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDM2→partner) and Y-score (partner→R3HDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.170	+1.220	<.001	<.001	3	17
OESOPHAGUS	Cytosolic transport →	+0.086	+1.629	<.001	<.001	3	16
OESOPHAGUS	Cilium or flagellum-dependent cell motility →	-0.116	-1.461	<.001	<.001	3	15
STOMACH	Negative regulation of transcription by RNA polymerase III →	+0.172	+1.241	<.001	<.001	3	15
SOFT_TISSUE	Flagellated sperm motility →	-0.108	-0.954	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription elongation by RNA polymerase II →	+0.134	+0.837	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,700 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by R3HDM2 expression — OESOPHAGUS

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