R3HDM2

Across TCGA cell cohorts, R3HDM2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible R3HDM2-associated genes across cancer lineages are GUCA1A, PRAMEF12, and OR52N2. Each is linked with R3HDM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HDM2-to-partner and partner-to-R3HDM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1A grouped by R3HDM2-low versus R3HDM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDM2→partner) and Y-score (partner→R3HDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GUCA1A →	+0.039	+3.104	.002	.002	3	2
LUNG_SCLC	PRAMEF12 →	+0.172	+4.269	<.001	.005	3	1
LUNG_SCLC	OR52N2 →	+0.081	+4.044	.006	.009	3	1
LUNG_SCLC	OR56B1 →	+0.085	+4.269	<.001	.005	3	1
LUNG_SCLC	MBD3L2 →	+0.755	+4.523	<.001	.003	3	1
LUNG_SCLC	PRAMEF5 →	+0.049	+5.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GUCA1A by R3HDM2 expression — LARGE_INTESTINE

Explore this box plot interactively →