R3HCC1L

Across TCGA cell cohorts, R3HCC1L mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible R3HCC1L-associated genes across cancer lineages are KLK12, IFNA14, and SPDYE4. Each is linked with R3HCC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HCC1L-to-partner and partner-to-R3HCC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK12 grouped by R3HCC1L-low versus R3HCC1L-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HCC1L→partner) and Y-score (partner→R3HCC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	1
SKIN	SPDYE4 →	+0.022	+3.930	<.001	.003	3	1
SKIN	SLC15A5 →	+0.039	+4.562	<.001	<.001	3	1
OVARY	OR2T4 →	+0.025	+4.807	<.001	.003	3	1
OVARY	OR2L8 →	+0.041	+4.450	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

KLK12 by R3HCC1L expression — SOFT_TISSUE

Explore this box plot interactively →