R3HCC1

Across TCGA patient cohorts, R3HCC1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible R3HCC1-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and JNK2. Each is linked with R3HCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HCC1-to-partner and partner-to-R3HCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by R3HCC1-low versus R3HCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HCC1→partner) and Y-score (partner→R3HCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.153	-3.143	.003	.018	3	1
UCEC	A-Raf_pS299 →	-0.197	-3.169	.001	.019	3	1
UCEC	JNK2 →	+0.213	+2.817	.040	.036	3	1
UCEC	Heregulin →	-0.159	-3.169	.013	.019	2	1
UCEC	N-Ras →	-0.164	-3.308	.008	.010	2	1
UCEC	P-Cadherin →	-0.208	-3.159	.005	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

14-3-3_beta by R3HCC1 expression — UCEC

Explore this box plot interactively →