R3HCC1

Across TCGA cell cohorts, R3HCC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,235 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible R3HCC1-associated GO terms across cancer lineages are Negative regulation of regulatory ncRNA-mediated heterochromatin formation, Regulation of regulatory ncRNA-mediated heterochromatin formation, and piRNA-mediated gene silencing by mRNA destabilization. Each is linked with R3HCC1 in more than 13 cancer types. Because this analysis shows association rather than direction, both R3HCC1-to-partner and partner-to-R3HCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of regulatory ncRNA-mediated heterochromatin formation grouped by R3HCC1-low versus R3HCC1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HCC1→partner) and Y-score (partner→R3HCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.129	+0.873	.003	.006	2	14
LIVER	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.129	+0.873	.003	.006	2	14
LARGE_INTESTINE	piRNA-mediated gene silencing by mRNA destabilization →	+0.215	+0.719	<.001	<.001	3	12
SOFT_TISSUE	Negative regulation of sister chromatid cohesion →	+0.117	+0.624	.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Spindle assembly →	+0.076	+0.752	.002	.002	3	10
URINARY_TRACT	DNA replication-dependent chromatin assembly →	+0.078	+0.925	.009	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,235 associations by consensus.

Negative regulation of regulatory ncRNA-mediated heterochromatin formation by R3HCC1 expression — LIVER

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