R3HCC1

Across TCGA cell cohorts, R3HCC1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible R3HCC1-associated genes across cancer lineages are ECE2, FOXI3, and PF4. Each is linked with R3HCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HCC1-to-partner and partner-to-R3HCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by R3HCC1-low versus R3HCC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HCC1→partner) and Y-score (partner→R3HCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.340	+4.054	<.001	.004	3	1
LARGE_INTESTINE	FOXI3 →	+0.523	+4.155	.002	.003	3	1
SKIN	PF4 →	+0.295	+3.453	.008	.009	3	1
LUNG_NSCLC_LUAD	SUPT20HL1 →	+0.006	+4.947	.001	.001	3	1
SKIN	CYYR1 →	+1.192	+3.554	<.001	.007	1	1
LUNG_NSCLC_LUAD	AQP12B →	+0.020	+4.417	.002	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ECE2 by R3HCC1 expression — LARGE_INTESTINE

Explore this box plot interactively →