QSOX2

Across TCGA cell cohorts, QSOX2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible QSOX2-associated genes across cancer lineages are NKX2-6, SERPINA7, and C1orf158. Each is linked with QSOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both QSOX2-to-partner and partner-to-QSOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by QSOX2-low versus QSOX2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QSOX2→partner) and Y-score (partner→QSOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NKX2-6 →	+0.052	+5.169	<.001	<.001	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
LUNG_SCLC	LUZP4 →	+0.994	+4.044	<.001	.009	3	1
LUNG_SCLC	OR10G3 →	+0.047	+4.643	<.001	.004	3	1
LUNG_SCLC	PAGE3 →	+0.047	+4.817	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

NKX2-6 by QSOX2 expression — LUNG_SCLC

Explore this box plot interactively →