QSOX1

Across TCGA pan-cancer cohorts, QSOX1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated QSOX1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher QSOX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated QSOX1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where QSOX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.917	1.000	.011	60	view →
HNSC	DFS	Median	All	0.864	0.707	.002	48	view →
CCRCC	DFS	Median	III,IV	0.105	0.928	.003	41	view →
PDAC	DFS	Tertile	IV	0.199	0.934	.024	11	view →
LUAD	OS	Tertile	III,IV	0.352	1.000	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

QSOX1–COAD (DFS)

Open the COAD breakdown →