QSOX1

Across TCGA patient cohorts, QSOX1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QSOX1-associated genes across cancer lineages are EGFR_pY1068, P-Cadherin, and XBP1. Each is linked with QSOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both QSOX1-to-partner and partner-to-QSOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by QSOX1-low versus QSOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QSOX1→partner) and Y-score (partner→QSOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.219	-1.925	.005	.004	3	2
UCEC	P-Cadherin →	-0.110	-2.222	.015	.009	3	2
UCEC	XBP1 →	-0.101	-1.687	.023	.040	3	2
UCEC	14-3-3_beta →	-0.074	-1.558	.019	.032	3	1
UCEC	eEF2 →	+0.326	+1.353	.003	.015	3	1
UCEC	eIF4E →	+0.153	+1.836	.021	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

EGFR_pY1068 by QSOX1 expression — UCEC

Explore this box plot interactively →