QPRT

Across TCGA patient cohorts, QPRT mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible QPRT-associated genes across cancer lineages are GTF2F2P2, OR2Y1, and PRR23B. Each is linked with QPRT in more than 1 cancer types. Because this analysis shows association rather than direction, both QPRT-to-partner and partner-to-QPRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTF2F2P2 grouped by QPRT-low versus QPRT-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QPRT→partner) and Y-score (partner→QPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GTF2F2P2 →	+0.076	+5.251	.001	.006	3	2
BLCA	OR2Y1 →	+0.100	+5.899	<.001	.002	3	1
BLCA	PRR23B →	+0.060	+4.973	<.001	.009	3	1
BLCA	RN7SKP104 →	+0.151	+7.307	<.001	<.001	3	1
UCEC	PKN3 →	+0.887	+3.202	.001	.009	3	1
SKCM	RNU6-539P →	+0.267	+3.300	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

GTF2F2P2 by QPRT expression — BLCA

Explore this box plot interactively →