QPCTL

Across TCGA patient cohorts, QPCTL mutation is significantly associated with the RNA expression of many other genes, with 863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QPCTL-associated genes across cancer lineages are SPTLC1P3, RNU6-956P, and MIR7155. Each is linked with QPCTL in more than 1 cancer types. Because this analysis shows association rather than direction, both QPCTL-to-partner and partner-to-QPCTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPTLC1P3 grouped by QPCTL-low versus QPCTL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QPCTL→partner) and Y-score (partner→QPCTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPTLC1P3 →	+0.133	+4.436	<.001	.001	3	2
HNSC	RNU6-956P →	+0.763	+7.954	<.001	.008	3	2
UCEC	MIR7155 →	+0.333	+2.994	<.001	.002	3	2
BRCA	RNU6-1122P →	+0.259	+5.505	<.001	.002	3	2
BRCA	RNU6-193P →	+0.146	+7.473	<.001	.007	3	2
BRCA	RNU6-782P →	+0.250	+4.800	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 863 associations by consensus.

SPTLC1P3 by QPCTL expression — SKCM

Explore this box plot interactively →