QPCTL

Across TCGA pan-cancer cohorts, QPCTL RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of QPCTL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where QPCTL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types QPCTL is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where QPCTL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in QPCTL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+1.008	<.001	12	view →
KIRP	All	III,IV	+1.213	<.001	11	view →
HNSC	Male	III,IV	+1.045	<.001	11	view →
COAD	Female	All	+1.001	<.001	10	view →
LIHC	Female	II,III,IV	+1.227	<.001	9	view →
BLCA	All	III,IV	+0.857	<.001	9	view →
LUAD	Female	III,IV	+0.892	<.001	8	view →
LUSC	All	II,III,IV	+0.643	<.001	7	view →
UCEC	All	III,IV	+1.561	<.001	6	view →
BRCA	All	All	+0.429	<.001	6	view →
KICH	Female	II,III,IV	−1.268	<.001	5	view →
STAD	All	II,III,IV	+0.817	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

QPCTL–KIRC

Open the KIRC breakdown →