QKI

Across TCGA patient cohorts, QKI mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QKI-associated genes across cancer lineages are Notch1, JNK2, and MEK1. Each is linked with QKI in more than 1 cancer types. Because this analysis shows association rather than direction, both QKI-to-partner and partner-to-QKI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by QKI-low versus QKI-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QKI→partner) and Y-score (partner→QKI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Notch1 →	+0.191	+2.178	.028	.035	3	2
UCEC	JNK2 →	+0.188	+2.114	<.001	.002	3	2
UCEC	MEK1 →	+0.413	+1.584	<.001	<.001	3	2
UCEC	RAD51 →	+0.092	+1.392	.015	.017	3	2
UCEC	TFRC →	+0.542	+2.736	<.001	<.001	3	2
UCEC	Tuberin →	+0.286	+2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Notch1 by QKI expression — COAD

Explore this box plot interactively →