QDPR

Across TCGA cell cohorts, QDPR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,547 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible QDPR-associated GO terms across cancer lineages are Pteridine-containing compound biosynthetic process, Tetrahydrobiopterin metabolic process, and Tetrahydrobiopterin biosynthetic process. Each is linked with QDPR in more than 10 cancer types. Because this analysis shows association rather than direction, both QDPR-to-partner and partner-to-QDPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pteridine-containing compound biosynthetic process grouped by QDPR-low versus QDPR-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (QDPR→partner) and Y-score (partner→QDPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Pteridine-containing compound biosynthetic process →	+0.102	+0.606	.005	.007	2	11
STOMACH	Tetrahydrobiopterin metabolic process →	+0.141	+0.650	<.001	<.001	3	10
STOMACH	Tetrahydrobiopterin biosynthetic process →	+0.109	+0.668	<.001	<.001	3	9
LARGE_INTESTINE	Transcription pausing by RNA polymerase II →	+0.141	+0.785	<.001	<.001	3	9
SKIN	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.147	+1.357	.001	.001	3	8
BREAST	DNA-templated transcription elongation →	+0.055	+0.888	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,547 associations by consensus.

Pteridine-containing compound biosynthetic process by QDPR expression — STOMACH

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