QARS1

Across TCGA cell cohorts, QARS1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible QARS1-associated genes across cancer lineages are MAGEB4, KCNJ5, and USO1. Each is linked with QARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both QARS1-to-partner and partner-to-QARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by QARS1-low versus QARS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QARS1→partner) and Y-score (partner→QARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	KCNJ5 →	+0.592	+3.215	.002	.009	3	1
LARGE_INTESTINE	USO1 →	+0.660	+3.067	.001	.009	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.008	+2.777	<.001	.004	3	1
LARGE_INTESTINE	ZNF454 →	+0.261	+3.144	<.001	.001	3	1
BLOOD_Lymphoma	AGTR2 →	+0.023	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MAGEB4 by QARS1 expression — LARGE_INTESTINE

Explore this box plot interactively →