PZP

Across TCGA patient cohorts, PZP mutation is significantly associated with the RNA expression of many other genes, with 4,666 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PZP-associated genes across cancer lineages are FEN1, HJURP, and TROAP. Each is linked with PZP in more than 4 cancer types. Because this analysis shows association rather than direction, both PZP-to-partner and partner-to-PZP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEN1 grouped by PZP-low versus PZP-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PZP→partner) and Y-score (partner→PZP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FEN1 →	+0.561	+2.016	.001	.005	3	5
STAD	HJURP →	+0.656	+3.700	.003	.001	3	5
STAD	TROAP →	+0.764	+3.236	<.001	<.001	3	5
SKCM	TEDC2 →	+0.430	+1.741	<.001	.001	3	5
SKCM	AURKB →	+0.508	+1.604	<.001	<.001	3	5
UCEC	WDHD1 →	+0.409	+2.343	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,666 associations by consensus.

FEN1 by PZP expression — STAD

Explore this box plot interactively →