PZP

Across TCGA pan-cancer cohorts, PZP RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PZP data layer compared with 8 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PZP RNA is associated with better overall survival. In most high-consensus cancer types, elevated PZP expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

SKCM, UCEC, and KIRP are the cancer types where PZP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.413	0.267	<.001	80	view →
UCEC	OS	Tertile	All	0.962	0.900	.002	56	view →
KIRP	OS	Median	II,III,IV	0.254	0.822	.004	53	view →
HNSC	DFS	Quartile	IV	0.566	0.290	.002	29	view →
LIHC	OS	Quartile	All	0.624	0.409	.001	28	view →
LAML	DFS	Tertile	All	0.193	0.480	.009	26	view →
THCA	DFS	Median	All	0.971	0.916	.002	25	view →
CESC	DFS	Quartile	IV	0.794	0.183	.014	18	view →
SARC	OS	Median	All	0.850	0.674	.009	15	view →
BRCA	OS	Tertile	III,IV	0.633	0.418	.027	14	view →
THYM	OS	Tertile	All	0.898	1.000	.013	14	view →
UCS	DFS	Quartile	All	0.198	0.517	.041	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PZP–SKCM (OS)

Open the SKCM breakdown →