PZP

Across TCGA patient cohorts, PZP mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PZP-associated genes across cancer lineages are Caspase-7-cleavedD198, ER-alpha_pS118, and 4E-BP1. Each is linked with PZP in more than 3 cancer types. Because this analysis shows association rather than direction, both PZP-to-partner and partner-to-PZP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PZP-low versus PZP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PZP→partner) and Y-score (partner→PZP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.943	+1.593	.002	.043	3	4
BLCA	ER-alpha_pS118 →	+0.122	+2.321	.026	.035	3	3
UCEC	4E-BP1 →	+0.313	+2.502	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.498	+1.485	.002	.003	3	3
UCEC	STAT3_pY705 →	-0.297	-1.440	<.001	.020	3	3
UCEC	beta-Catenin →	+0.298	+1.415	.043	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Caspase-7-cleavedD198 by PZP expression — COAD

Explore this box plot interactively →