PZP

Across TCGA cell cohorts, PZP RNA expression is significantly associated with the go_rna of many other GO terms, with 537 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PZP-associated GO terms across cancer lineages are Lysosomal lumen acidification, Negative regulation of toll-like receptor 3 signaling pathway, and Sulfur compound catabolic process. Each is linked with PZP in more than 3 cancer types. Because this analysis shows association rather than direction, both PZP-to-partner and partner-to-PZP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal lumen acidification grouped by PZP-low versus PZP-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PZP→partner) and Y-score (partner→PZP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Lysosomal lumen acidification →	+0.052	+0.044	.009	.008	3	4
LUNG_NSCLC_LUAD	Negative regulation of toll-like receptor 3 signaling pathway →	-0.123	-0.051	<.001	.007	3	3
LUNG_NSCLC_LUAD	Sulfur compound catabolic process →	+0.059	+0.034	.001	.008	3	3
LARGE_INTESTINE	mRNA catabolic process →	+0.042	+0.007	.005	.006	3	3
LIVER	Alcohol metabolic process →	+0.080	+0.065	<.001	.004	3	3
LIVER	Protein N-linked glycosylation →	+0.084	+0.073	<.001	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 537 associations by consensus.

Lysosomal lumen acidification by PZP expression — BLOOD_Leukemia

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