PZP

Across TCGA cell cohorts, PZP mutation is significantly associated with the RNA expression of many other genes, with 160 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PZP-associated genes across cancer lineages are KRTAP5-11, EDDM3B, and OR5B21. Each is linked with PZP in more than 1 cancer types. Because this analysis shows association rather than direction, both PZP-to-partner and partner-to-PZP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-11 grouped by PZP-low versus PZP-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PZP→partner) and Y-score (partner→PZP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP5-11 →	+0.015	+3.977	<.001	.007	3	2
BLOOD_Lymphoma	EDDM3B →	+0.558	+4.452	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	OR5B21 →	+0.058	+4.209	<.001	.006	3	2
CNS	OOSP3 →	+0.046	+3.719	.002	.009	3	2
SKIN	ADGRA1 →	+0.004	+2.773	<.001	<.001	3	2
SKIN	OR6C68 →	+0.015	+3.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 160 associations by consensus.

KRTAP5-11 by PZP expression — SOFT_TISSUE

Explore this box plot interactively →