PYY

Across TCGA patient cohorts, PYY RNA expression is significantly associated with the go_rna of many other GO terms, with 7,116 significant associations in total. THCA shows the largest number of these associations.

The most reproducible PYY-associated GO terms across cancer lineages are Arginine biosynthetic process, Iron-sulfur cluster assembly, and Regulation of protein folding. Each is linked with PYY in more than 12 cancer types. Because this analysis shows association rather than direction, both PYY-to-partner and partner-to-PYY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Arginine biosynthetic process grouped by PYY-low versus PYY-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYY→partner) and Y-score (partner→PYY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Arginine biosynthetic process →	+0.068	+0.368	<.001	.001	3	13
DLBC	Iron-sulfur cluster assembly →	+0.069	+0.254	.004	<.001	2	13
STAD	Regulation of protein folding →	+0.086	+0.515	<.001	<.001	3	11
STAD	Nucleoside phosphate biosynthetic process →	+0.067	+0.414	<.001	.006	1	12
STAD	Nucleoside triphosphate biosynthetic process →	+0.092	+0.643	<.001	<.001	3	10
STAD	Protein hydroxylation →	+0.065	+0.407	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,116 associations by consensus.

Arginine biosynthetic process by PYY expression — ESCA

Explore this box plot interactively →