PYY

Across TCGA pan-cancer cohorts, PYY RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PYY data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PYY RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PYY expression acts as an unfavorable survival marker, although some lineages such as BRCA and UVM show a favorable association.

ACC, BRCA, and KIRC are the cancer types where PYY RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.366	0.778	<.001	171	view →
BRCA	OS	Median	All	0.952	0.895	<.001	73	view →
KIRC	DFS	Tertile	All	0.555	0.714	.001	69	view →
UVM	DFS	Tertile	All	0.684	0.398	.008	34	view →
GBM	OS	Tertile	All	0.310	0.493	.003	30	view →
PCPG	DFS	Tertile	All	0.655	0.883	.005	21	view →
HNSC	DFS	Median	All	0.438	0.251	.007	19	view →
UCEC	DFS	Median	All	0.927	0.866	.008	16	view →
OV	OS	Median	All	0.875	0.806	.019	14	view →
READ	DFS	Median	IV	0.760	0.382	.012	13	view →
STAD	OS	Tertile	IV	0.755	0.326	.019	12	view →
SKCM	OS	Quartile	IV	0.823	0.242	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PYY–ACC (DFS)

Open the ACC breakdown →