PYY

Across TCGA patient cohorts, PYY mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible PYY-associated genes across cancer lineages are CMP, MPP, and DC. Each is linked with PYY in more than 1 cancer types. Because this analysis shows association rather than direction, both PYY-to-partner and partner-to-PYY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMP grouped by PYY-low versus PYY-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYY→partner) and Y-score (partner→PYY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CMP →	+0.038	+3.315	<.001	.040	3	2
COAD	MPP →	+0.037	+3.403	<.001	.035	3	2
UCEC	DC →	+0.026	+2.871	.036	.034	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CMP by PYY expression — LUSC

Explore this box plot interactively →