PYURF

Across TCGA patient cohorts, PYURF mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYURF-associated genes across cancer lineages are MIR425, RNA5SP124, and RN7SKP224. Each is linked with PYURF in more than 1 cancer types. Because this analysis shows association rather than direction, both PYURF-to-partner and partner-to-PYURF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR425 grouped by PYURF-low versus PYURF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYURF→partner) and Y-score (partner→PYURF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR425 →	+0.638	+3.329	<.001	.004	3	1
UCEC	RNA5SP124 →	+0.481	+2.996	.003	.009	3	1
UCEC	RN7SKP224 →	+0.184	+3.718	.002	.004	3	1
UCEC	TRAJ57 →	+0.750	+3.734	<.001	.001	3	1
UCEC	BOLA3P3 →	+0.521	+3.510	.001	.007	3	1
UCEC	ZDHHC20P1 →	+0.364	+3.598	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MIR425 by PYURF expression — UCEC

Explore this box plot interactively →