PYURF

Across TCGA pan-cancer cohorts, PYURF RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PYURF’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PYURF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PYURF is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

HNSC, LUAD, and CHOL are the cancer types where PYURF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PYURF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.514	.002	8	view →
LUAD	Female	II,III,IV	−0.504	<.001	6	view →
CHOL	All	All	+0.631	<.001	4	view →
LIHC	Male	All	+0.497	<.001	4	view →
KICH	All	All	−0.301	.002	3	view →
ESCA	All	All	+0.597	<.001	2	view →
PAAD	Female	All	+0.209	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PYURF–HNSC

Open the HNSC breakdown →