PYROXD2

Across TCGA cell cohorts, PYROXD2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PYROXD2-associated genes across cancer lineages are DEFB136, GPR119, and FAM47B. Each is linked with PYROXD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYROXD2-to-partner and partner-to-PYROXD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB136 grouped by PYROXD2-low versus PYROXD2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYROXD2→partner) and Y-score (partner→PYROXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB136 →	+0.229	+6.266	<.001	<.001	3	1
BLOOD_Lymphoma	GPR119 →	+0.022	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	FAM47B →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	GAGE12F →	+0.668	+5.209	.008	.005	3	1
BLOOD_Lymphoma	TP53TG3E →	+0.035	+5.209	<.001	.005	3	1
LARGE_INTESTINE	ACER1 →	+0.085	+4.145	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

DEFB136 by PYROXD2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →