PYROXD1

Across TCGA patient cohorts, PYROXD1 mutation is significantly associated with the RNA expression of many other genes, with 2,497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYROXD1-associated genes across cancer lineages are DEFB117, RN7SL840P, and LINC02438. Each is linked with PYROXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYROXD1-to-partner and partner-to-PYROXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB117 grouped by PYROXD1-low versus PYROXD1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYROXD1→partner) and Y-score (partner→PYROXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	DEFB117 →	+0.490	+5.421	<.001	.005	3	2
READ	RN7SL840P →	+0.429	+5.421	<.001	.005	3	2
LUAD	LINC02438 →	+0.835	+3.798	.002	.005	3	2
LUAD	OR8Q1P →	+0.277	+3.572	<.001	.007	3	2
UCEC	LINC02506 →	+0.886	+1.717	.007	.005	3	2
COAD	MIR5190 →	+0.885	+5.080	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,497 associations by consensus.

DEFB117 by PYROXD1 expression — READ

Explore this box plot interactively →