PYM1

Across TCGA patient cohorts, PYM1 mutation is significantly associated with the RNA expression of many other genes, with 1,196 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYM1-associated genes across cancer lineages are HSPE1-MOB4, MED28P6, and ZFRP1. Each is linked with PYM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYM1-to-partner and partner-to-PYM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPE1-MOB4 grouped by PYM1-low versus PYM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYM1→partner) and Y-score (partner→PYM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPE1-MOB4 →	+0.209	+3.536	<.001	<.001	3	1
BLCA	MED28P6 →	+0.174	+7.640	<.001	.009	3	1
SKCM	ZFRP1 →	+0.019	+5.039	<.001	.003	3	1
SKCM	FECHP1 →	+0.025	+4.614	.005	.006	3	1
SKCM	OR13K1P →	+0.043	+4.302	<.001	.002	3	1
COAD	MIR548F3 →	+0.361	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,196 associations by consensus.

HSPE1-MOB4 by PYM1 expression — UCEC

Explore this box plot interactively →