PYHIN1

Across TCGA patient cohorts, PYHIN1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,544 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PYHIN1-associated genes across cancer lineages are JAK3, ICOS, and CD7. Each is linked with PYHIN1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PYHIN1-to-partner and partner-to-PYHIN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYHIN1 versus JAK3 in COAD, with a Pearson correlation of 0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYHIN1→partner) and Y-score (partner→PYHIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JAK3 →	+1.125	+1.110	.001	.004	3	8
BRCA	ICOS →	+1.155	+0.931	<.001	<.001	3	8
COAD	CD7 →	+1.907	+1.055	.004	.004	3	8
BRCA	IGHV3-30 →	+2.761	+0.979	<.001	<.001	3	8
HNSC	GRAP2 →	+1.130	+1.037	<.001	<.001	3	7
HNSC	IL2RB →	+1.340	+1.086	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,544 associations by consensus.

PYHIN1 vs JAK3 — COAD

Explore this scatter interactively →