PYGO1

Across TCGA pan-cancer cohorts, PYGO1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PYGO1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PYGO1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PYGO1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

UCEC, LUAD, and GBM are the cancer types where PYGO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.620	1.000	.011	16	view →
LUAD	OS	Median	III,IV	0.819	0.288	.026	6	view →
GBM	OS	Quartile	All	0.578	0.298	.023	2	view →
LSCC	OS	Median	III,IV	0.433	0.810	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PYGO1–UCEC (OS)

Open the UCEC breakdown →