PYGO1

Across TCGA pan-cancer cohorts, PYGO1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PYGO1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PYGO1 RNA is repressed in tumor relative to normal tissue. In most cancer types PYGO1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where PYGO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PYGO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.242	<.001	12	view →
THCA	Male	II,III,IV	−1.076	<.001	10	view →
KICH	Female	All	−1.240	<.001	8	view →
COAD	All	All	−0.439	<.001	7	view →
BRCA	All	All	−0.540	<.001	6	view →
LUAD	All	All	−0.331	.008	5	view →
KIRP	Female	II,III,IV	+1.322	.001	4	view →
STAD	All	All	−0.800	.004	4	view →
LUSC	Male	III,IV	−1.415	.001	2	view →
UCEC	All	All	−1.230	<.001	2	view →
READ	All	All	−1.000	.011	2	view →
CHOL	All	All	+0.565	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PYGO1–KIRC

Open the KIRC breakdown →