PYGO1

Across TCGA patient cohorts, PYGO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,676 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PYGO1-associated proteins across cancer lineages are SARM1, PYGO1_S34, and DPYSL3. Each is linked with PYGO1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PYGO1-to-partner and partner-to-PYGO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGO1 versus SARM1 in COAD, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO1→partner) and Y-score (partner→PYGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SARM1 →	+0.508	+0.517	<.001	<.001	3	8
UCEC	PYGO1_S34 →	+0.824	+0.970	<.001	<.001	3	8
CCRCC	DPYSL3 →	+0.583	+0.700	<.001	<.001	3	8
OV	ANTXR1 →	+0.658	+0.734	<.001	.003	3	7
HNSC	MAP1A →	+0.567	+0.887	<.001	<.001	3	7
CCRCC	LMOD1 →	+0.838	+0.501	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,676 associations by consensus.

PYGO1 vs SARM1 — COAD

Explore this scatter interactively →