PYGO1

Across TCGA patient cohorts, PYGO1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,096 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PYGO1-associated genes across cancer lineages are TUB, AKT3, and RIC3. Each is linked with PYGO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PYGO1-to-partner and partner-to-PYGO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGO1 versus TUB in HNSC, with a Pearson correlation of 0.85.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO1→partner) and Y-score (partner→PYGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TUB →	+1.777	+1.369	<.001	<.001	3	5
HNSC	AKT3 →	+1.642	+2.131	.004	.001	3	4
HNSC	RIC3 →	+1.910	+1.492	<.001	<.001	3	4
HNSC	DIRAS1 →	+3.597	+2.199	<.001	<.001	3	4
HNSC	TLCD5 →	+2.385	+2.239	.001	<.001	3	4
HNSC	PRKD1 →	+1.473	+1.377	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,096 associations by consensus.

PYGO1 vs TUB — HNSC

Explore this scatter interactively →