PYGO1

Across TCGA patient cohorts, PYGO1 protein abundance is significantly associated with the protein abundance of many other proteins, with 13,908 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PYGO1-associated proteins across cancer lineages are HDGFL3, PEAK1, and SARM1. Each is linked with PYGO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PYGO1-to-partner and partner-to-PYGO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGO1 versus HDGFL3 in HNSC, with a Pearson correlation of 0.83.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO1→partner) and Y-score (partner→PYGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HDGFL3 →	+1.012	+2.015	.001	<.001	3	5
UCEC	PEAK1 →	+0.383	+1.316	<.001	<.001	3	4
HNSC	SARM1 →	+0.917	+2.117	<.001	<.001	3	4
HNSC	SEPTIN11 →	+0.832	+1.759	<.001	<.001	3	4
UCEC	SORBS3 →	+0.567	+0.996	<.001	<.001	3	4
HNSC	FBLN1 →	+1.388	+1.652	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,908 associations by consensus.

PYGO1 vs HDGFL3 — HNSC

Explore this scatter interactively →