PYGO1

Across TCGA patient cohorts, PYGO1 mutation is significantly associated with the RNA expression of many other genes, with 1,710 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGO1-associated genes across cancer lineages are FTH1P9, RN7SKP4, and SURF6P1. Each is linked with PYGO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PYGO1-to-partner and partner-to-PYGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTH1P9 grouped by PYGO1-low versus PYGO1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO1→partner) and Y-score (partner→PYGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FTH1P9 →	+0.051	+5.643	<.001	<.001	3	3
SKCM	RN7SKP4 →	+0.169	+3.216	<.001	.004	3	3
COAD	SURF6P1 →	+0.312	+5.283	<.001	.006	3	2
COAD	ELAVL4-AS1 →	+0.194	+5.602	<.001	.004	3	2
LUSC	RNA5SP235 →	+0.341	+4.324	<.001	.002	3	2
UCEC	ANAPC15 →	+0.422	+1.925	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,710 associations by consensus.

FTH1P9 by PYGO1 expression — SKCM

Explore this box plot interactively →